It seems similar to the issue raised in this thread: viewtopic.php?t=19680&hilit=brush+import+issue
However, this anomaly is occurring with some of Pixelmator's native brushes.
The issue sometimes manifests as dark lines (as opposed to the white line seen below) and at various scales. It really hampers painting functionality.
I'm running Pixelmator Pro 3.3.1 on 2019 MacBook Pro i9 2.4Gz with 32Gb RAM